Pairings shown with regional seed and overall record
All games on Friday, Nov. 3 at 7 p.m. unless indicated otherwise
Division IV, Region 15
9 Licking Valley (8-3) at 1 Steubenville (10-1)
13 Indian Valley (8-3) at 5 Columbus Ready (10-1)
7 Gallia Academy (9-2) at 2 Sheridan (10-1)
6 St. Clairsville (9-2) at 3 Columbus Hartley (8-2)
Division V, Region 19
9 Heath (9-2) at 1 Ironton (10-1)
5 West Muskingum (10-1) at 4 Harvest Prep (9-1)
15 Portsmouth (6-5) at 7 Wheelersburg (7-3)
6 Columbus Academy (10-1) at 3 Barnesville (11-0)
Division VI, Region 23
9 East Knox (7-4) at at 1 Garaway (11-0)
12 Trimble (6-4) at 4 Galion Northmor (9-2)
7 Nelsonville-York (8-3) at 2 West Jefferson (10-1)
11 Newcomerstown (7-4) at 3 Fort Frye (8-2)
Division VII, Region 27
8 Monroe Central (7-4) at 1 Meigs Eastern (10-1)
5 River (8-2) at 4 Fairfield Christian Academy (9-2)
7 Waterford (7-4) at 2 Pike Eastern (11-0)
6 Notre Dame (8-3) at 3 Caldwell (8-3)
