The 10 hits in an inning were the most in 17 years for the Reds, and the eight runs were their most this season. They opened the inning with six straight hits to knock Braves starter Horacio Ramirez out of the game.
Cincinnati had 16 hits in a 14-run first inning on Aug. 3, 1989, against Houston, the most in the major leagues since 1900.
Adam Dunn had a two-run single and Rich Aurilia hit a two-run homer as the Reds sent 13 batters to the plate in the big inning.
Ryan Freel had three hits and scored three runs for the Reds.
Eric Milton (5-4) gave up six hits and five runs in 6 1-3 innings.
Ramirez gave up seven hits and seven runs in one-plus innings as his ERA jumped from 3.47 to 4.83. He gave up the six straight hits in the second and was pulled.
Ramirez (4-3) saw his stretch of three straight strong starts come to an abrupt end. In two wins and a no-decision, the left-hander had given up a total of four earned runs.
In his last loss, however, Ramirez posted numbers similar to Friday night. On June 11, Ramirez lasted 1 2-3 innings, giving up seven hits and six runs in a 14-4 loss at Houston.
Reliever Oscar Villarreal gave up four more hits in the second inning, including Aurilia's homer.