Sandra Miller, 42, and George Miller III, 41, of Pikeville, Ky., are charged with the second-degree felonies of possession of drugs and trafficking in drugs.
According to the Chillicothe Post of the Ohio State Highway Patrol, they stopped a vehicle for a traffic stop on U.S. 23 in Pike County.
The OSHP says criminal indicators were observed and the Piketon Police Department responded to assist.
A search turned up 290 Oxycodone pills and 148 Alprazlam pills, troopers said.
Both were arrested and incarcerated in the Scioto County Jail.
FRANK LEWIS may be reached at (740) 353-3101, ext. 232, or email@example.com.